Selective Regulation of MMP and TIMP mRNA Levels in Tree Shrew Sclera during Minus Lens Compensation and Recovery
نویسندگان
چکیده
منابع مشابه
Patterns of mRNA and protein expression during minus-lens compensation and recovery in tree shrew sclera
PURPOSE To increase our understanding of the mechanisms that remodel the sclera during the development of lens-induced myopia, when the sclera responds to putative "go" signals of retinal origin, and during recovery from lens-induced myopia, when the sclera responds to retinally-derived "stop" signals. METHODS Seven groups of tree shrews were used to examine mRNA levels during minus lens comp...
متن کاملSelective modulation of scleral proteoglycan mRNA levels during minus lens compensation and recovery.
PURPOSE To better characterize the role of proteoglycans in scleral tissue remodeling during the development of minus lens induced myopia and during recovery in tree shrews. METHODS Competitive reverse-transcription polymerase chain reaction (RT-PCR) was used to quantify the scleral mRNA levels for aggrecan, decorin, biglycan, and lumican in a group of tree shrews following four days of monoc...
متن کاملModulation of glycosaminoglycan levels in tree shrew sclera during lens-induced myopia development and recovery.
PURPOSE In juvenile tree shrews, positioning a negative-power lens in front of an eye produces a hyperopic shift in refractive state and causes a compensatory increase in axial length over several days so that the eye is myopic when the lens is removed. During negative lens compensation, the scleral extracellular matrix is remodeled. A biomechanical property of the sclera, creep rate, increases...
متن کاملSteady state mRNA levels in tree shrew sclera with form-deprivation myopia and during recovery.
PURPOSE In tree shrews, visual form deprivation induces myopia and tissue remodeling in the sclera, characterized by decreased levels of collagen and glycosaminoglycans (GAGs) and increased levels of matrix metalloproteinases (MMPs). Removal of the visual deprivation allows recovery. This study investigated whether these changes are accompanied by changes in steady state mRNA levels in the scle...
متن کاملAlterations in protein expression in tree shrew sclera during development of lens-induced myopia and recovery.
PURPOSE During the development of, and recovery from, negative lens-induced myopia there is regulated remodeling of the scleral extracellular matrix (ECM) that controls the extensibility of the sclera. Difference gel electrophoresis (DIGE) was used to identify and categorize proteins whose levels are altered in this process. METHODS Two groups of five tree shrews started monocular lens wear 2...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2005
ISSN: 1552-5783
DOI: 10.1167/iovs.05-0194